PIMPINELLA TIRUPATIENSIS IMPROVES THE LEVELS OF BRAIN CARBOHYDRATE METABOLIC PROFILES IN STREPTOZOTOCIN-INDUCED DIABETIC RATS

The present study was designed to investigate the protective role of Pimpinella tirupatiensis on the carbohydrate metabolic profiles in STZ-induced diabetic rats. Wistar strain male albino rats were divided in to 5 groups as stated in the experimental protocol. The parameters studied are total carbohydrates, total proteins, glycogen and free amino acids. These metabolic profiles were decreased in diabetic rats except glycogen. Whereas, with Pimpinella tirupatiensis treatment in diabetic rats these carbohydrate metabolic profiles were up regulated and glycogen down regulated. The blood glucose levels were also came to normalcy in Pimpinella tirupatiensis treated diabetic rats. The observed reductions in carbohydrate metabolic profiles during diabetic condition in brain tissue may be due to the alterations in the carbohydrate metabolism. From the results, it is concluded that Pimpinella tirupatiensis posse’s hypoglycemic property and other pharmacological properties so in diabetic rats, all these carbohydrate metabolic profiles were came to normalcy.

Key words: Pimpinella tirupatiensis, diabetes, total carbohydrates, blood glucose, brain