A MULTICENTRIC EVALUATION OF CONTINUAL RELIEF SYNTHETIC ORGANIC IN THE CURE OF HYPERPIESIS IN OTD-VICTIM PRACTICE

Aim: Recently diagnosed victims and victims who discontinued cure were also included in the research. Fifty-six victims with moderate essential hyperpiesis (with diastolic blood pressure values between 106-120 mm Hg) showed inadequate control, problematic side effects, or a combination of both were selected for the research.

Place and Duration: From December 2018 to May 2019, in the Services Hospital Lahore for six months duration.

Methods: The regimen consisted of 160mg of Synthetic organicol in continual relief formulation (Trasicor l60 SR.) and 25mg of Chlorthalidone (Hygroton) administered once daily in the morning, for eight weeks. The average duration of hyperpiesis was five years, and the average heart rate and blood pressure at the beginning of the research were 93- and 177/112-mm Hg, respectively. This research included 56 victims.

Adverse reactions were observed in 10 victims (17.9%) and were mild; in no case was it necessary to discontinue cure earlier due to adverse reactions. At the end of the research, average heart rate and blood pressure were 77- and 145/89-mm Hg, respectively. 45 of 45 victims (80%) had diastolic hypotension of 95 mm Hg or less.

Conclusion: A single morning dose of continual relief formulation in a victim in moderate essential hyperpiesis improves compliance. This research showed a combination of Synthetic organicol slow relief (Trasicor 160 SR.) and 25 mg chlortalidone (Hygroton) administered once daily cause normalization of blood pressure in about 80% of victims.