COMPARATIVE DISSOLUTION STUDIES OF PROPRANOLOL HCL BY USING DIFFERENT TECHNIQUES

Propranolol HCl is a beta blocker used for sudden anginal attacks and tremors due to fear etc. Rapid disintegration of the tablet is desired to achieve quick onset of action. For this, suitable disintegrants must be added and tablet must disintegrate within seconds. From this experiment it was found that CPV (an insoluble superdisintegrants) gives fastest disintegration attributed to its high swelling properties and the optimum concentration of CPV is 8%.

Tablets were prepared by using three methods of which Effervescent method is evolved as best. The optimized formulation is subject to stability studies for 4 weeks by storing them at 40C/75%RH. Results of physical appearance, hardness, friability, disintegration test, and drug content have shown that there is no significant change at storage condition.

Keywords: Propranolol HCl, hardness, friability, disintegration test, and drug content.