FORMULATION AND EVALUATION OF CONTROLLED RELEASED GASTRO RETENTIVE FLOATING TABLETS OF SUMATRIPTAN SUCCINATE BY USING DIFFERENT POLYMERS

Floating tablets containing Sumatriptan succinate were prepared by wet granulation  technique using variable concentrations of , HPMCK100M, Xanthan gum and guar gum , with gas generating agent such as sodium bicarbonate.The present investigation to provide a pharmaceutical composition in the form of tablets which constitutes an oral controlled gastric retention drug delivery system of sumatriptan succinate .The consequences of the current examination in this way plainly showed that GFDDS for sumatriptan succinate were effectively figured by utilizing various evaluations of hydrophilic polymers, for example, HPMC K100, xanthan and guargum. From the outcomes it very well may be presumed that F11 with HPMC K100M, and sodium bicarbonate as gas creating specialist gives the 99.92 % of drug discharge up to 12hours

Keywords: Sumatriptan succinate , hydrophilic polymers, HPMC K100, xanthan and guargum