Target Enabling Packages (TEPs)
Published November 27, 2020 | Version 1
Dataset Open

Elongation of very long chain fatty acids protein 7 (ELOVL7); A Target Enabling Package

Creators

  • 1. Centre for Medicines Discovery, Old Road Campus Research Building, Headington, Oxford OX3 7DQ, UK
  • 2. Albert Einstein College of Medicine, Department of Biochemistry, New York, NY 10461-1602, USA

Description

The long-chain fatty acid elongases (ELOVL) catalyse the first rate-limiting step in the two carbon elongation of the acyl chains of fatty acids (FAs) greater than 12 carbons in length. Defects in these ELOVL elongases cause severe genetic diseases, such as Stargardt disease-3 and several ataxias, and knockout studies suggest roles in insulin resistance and hepatic steatosis. This TEP provides the first structural information for this family of enzymes which, coupled with mutagenesis and biophysical studies, demonstrates how substrates and products bind within the active site.

Notes

This document represents version 1 of the TEP datasheet and includes all updates on the project as of November 2020. For more information about TEPs and the TEP Programme, please visit https://thesgc.org/tep.

Files

ELOVL7 TEP_v1.pdf

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Additional details

Related works

Is part of
https://www.thesgc.org/tep (URL)

Funding

Wellcome Trust
A UK Hub to Catalyse Open Target Discovery. 106169