Published November 27, 2020
| Version 0
Dataset
Open
Elongation of very long chain fatty acids protein 7 (ELOVL7); A Target Enabling Package
Authors/Creators
- 1. Centre for Medicines Discovery, Old Road Campus Research Building, Headington, Oxford OX3 7DQ, UK
- 2. Albert Einstein College of Medicine, Department of Biochemistry, New York, NY 10461-1602, USA
Description
The long-chain fatty acid elongases (ELOVL) catalyse the first rate-limiting step in the two carbon elongation of the acyl chains of fatty acids (FAs) greater than 12 carbons in length. Defects in these ELOVL elongases cause severe genetic diseases, such as Stargardt disease-3 and several ataxias, and knockout studies suggest roles in insulin resistance and hepatic steatosis. This TEP provides the first structural information for this family of enzymes which, coupled with mutagenesis and biophysical studies, demonstrates how substrates and products bind within the active site.
Notes
Future versions of this TEP will contain experimental data on the ELOVL7 TEP.
Files
ELOVL7_TEP_v0.pdf
Files
(485.1 kB)
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Additional details
Related works
- Is part of
- https://www.thesgc.org/tep (URL)
Funding
- Wellcome Trust
- A UK Hub to Catalyse Open Target Discovery. 106169