stephane-mottin
Published April 18, 2008 | Version v1
Journal article Open

Measuring brain hemodynamic changes in a songbird: responses to hypercapnia measured with functional MRI and near-infrared spectroscopy

Authors/Creators

  • 1. NAMC; UMR CNRS; University Paris XI; UJM; Paris; St-Etienne; France
  • 2. Bio-Imaging Lab; UA; Antwerp; Belgium
  • 3. lab. Curien. CNRS UJM UdL; Saint-Etienne; France

Contributors

Contact person:

  • 1. lab. Curien. CNRS UJM UdL; Saint-Etienne; France

Description

Songbirds have been evolved into models of choice for the study of the cerebral underpinnings of vocal communication. Nevertheless, there is still a need for in vivo methods allowing the real-time monitoring of brain activity. Functional Magnetic Resonance Imaging (fMRI) has been applied in anesthetized intact songbirds. It relies on blood oxygen level-dependent (BOLD) contrast revealing hemodynamic changes. Non-invasive near-infrared spectroscopy (NIRS) is based on the weak absorption of near-infrared light by biological tissues. Time-resolved femtosecond white laser NIRS is a new probing method using real-time spectral measurements which give access to the local variation of absorbing chromophores such as hemoglobins. In this study, we test the efficiency of our time-resolved NIRS device in monitoring physiological hemodynamic brain responses in a songbird, the zebra finch (Taeniopygia guttata), using a hypercapnia event (7% inhaled CO(2)). The results are compared to those obtained using BOLD fMRI. The NIRS measurements clearly demonstrate that during hypercapnia the blood oxygen saturation level increases (increase in local concentration of oxyhemoglobin, decrease in deoxyhemoglobin concentration and total hemoglobin concentration). Our results provide the first correlation in songbirds of the variations in total hemoglobin and oxygen saturation level obtained from NIRS with local BOLD signal variations.

Notes

License CC-BY-NC-ND. Feature Article; IOP select - highlights-. --------- French law about open access and open science: https://www.legifrance.gouv.fr/affichTexte.do?cidTexte=JORFTEXT000033202746&categorieLien=id ----------- (LOI n° 2016-1321 du 7 octobre 2016 pour une République numérique - Article 30);

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Additional details

Related works

Is cited by
https://cv.archives-ouvertes.fr/stephane-mottin (URL)
10.1088/0031-9155/53/10/001 (DOI)

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Subjects

Physical sciences
http://id.loc.gov/authorities/subjects/sh89005705.html
Optics
http://id.loc.gov/authorities/subjects/sh85095181.html
Neurophysiology
http://id.loc.gov/authorities/subjects/sh85091159.html
Neurosciences
http://id.loc.gov/authorities/subjects/sh91006099.html