Published April 7, 2020
| Version v1
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Why Warburg Works: Lactate Controls Immune Evasion through GPR81
- 1. Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, The Mærsk Tower, The Panum Institute, 2200 Copenhagen, Denmark; Department of Biology, Faculty of Science, University of Copenhagen, 2100 Copenhagen, Denmark
- 2. Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, The Mærsk Tower, The Panum Institute, 2200 Copenhagen, Denmark
- 3. Department of Biology, Faculty of Science, University of Copenhagen, 2100 Copenhagen, Denmark
Description
Lactate accumulation in tumors-a hallmark of the Warburg effect-has recently been shown to regulate cancer cell metabolism and survival through autocrine activation of GPR81. Now, Brown et al. (2020) demonstrate that lactate surprisingly also controls immune evasion through paracrine activation of GPR81 on stromal dendritic cells.
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