Published December 9, 2020
| Version v1.5
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Minimal genome-wide human CRISPR-Cas9 library
Description
Minimal genome-wide human CRISPR-Cas9 library release
CRISPR guide-RNA libraries have been iteratively improved to provide increasingly efficient reagents, although their large size is a barrier for many applications. We design an optimised minimal genome-wide human CRISPR-Cas9 library (MinLibCas9) by mining existing large-scale gene loss-of-function datasets, resulting in a greater than 42% reduction in size compared to other CRISPR-Cas9 libraries while preserving assay sensitivity and specificity. MinLibCas9 provides backward compatibility with existing datasets, increases the dynamic range of CRISPR-Cas9 screens and extends their application to complex models and assays.
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EmanuelGoncalves/crispy-v1.5.zip
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(258.5 MB)
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Related works
- Is supplement to
- https://github.com/EmanuelGoncalves/crispy/tree/v1.5 (URL)