A disease-specific functional connectome of Parkinson's disease patients.
- Loh, Aaron1
- Boutet, Alexandre2
- Germann, Jurgen1
- Al-Fatly, Bassam3
- Elias, Gavin J.B.1
- Neudorfer, Clemens1
- Krotz, Jillian4
- Wong, Emily H.Y.1
- Parmar, Roohie1
- Gramer, Robert1
- Paff, Michelle1
- Horn, Andreas3
- Chen, J. Jean4
- Azevedo, Paula5
- Fasano, Alfonso6
- Munhoz, Renato P.7
- Hodaie, Mojgan8
- Kalia, Suneil K.8
- Kucharczyk, Walter9
- Lozano, Andres M.8
- 1. Krembil Neuroscience Center. University Health Network, Toronto, Ontario, Canada
- 2. Krembil Neuroscience Center. University Health Network, Toronto, Ontario, Canada; Joint Department of Medical Imaging, University of Toronto, Toronto, Ontario, Canada
- 3. Department of Neurology with Experimental Neurology, Movement Disorders and Neuromodulation Unit, Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany
- 4. Rotman Research Institute, Baycrest Health Sciences, Toronto, Canada; Department of Medical Biophysics, University of Toronto, Canada.
- 5. Edmond J. Safra Program in Parkinson's Disease, Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, University Health Network, Division of Neurology, University of Toronto, Toronto, Ontario, Canada
- 6. Edmond J. Safra Program in Parkinson's Disease, Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, University Health Network, Division of Neurology, University of Toronto, Toronto, Ontario, Canada; Krembil Brain Institute, Toronto, Ontario, Canada; CenteR for Advancing Neurotechnological Innovation to Application (CRANIA)
- 7. Edmond J. Safra Program in Parkinson's Disease, Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, University Health Network, Division of Neurology, University of Toronto, Toronto, Ontario, Canada; Krembil Brain Institute, Toronto, Ontario, Canada
- 8. Krembil Neuroscience Center. University Health Network, Toronto, Ontario, Canada; Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada
- 9. Joint Department of Medical Imaging, University of Toronto, Toronto, Ontario, Canada
Description
The contribution of the presented work is a data record featuring a disease-specific dataset of resting state functional magnetic resonance imaging (rs-fMRI) acquisitions of 75 Parkinson's disease (PD) patients prior to deep brain stimulation (DBS) implantation - the Tor-PD connectome. Specifically, the dataset comprises 77 matrices (in the folder entitled 'vol'), each containing blood-oxygen-level-dependent-signal (BOLD) signal values of every voxel in 77 corresponding rs-fMRI acquisitions in standard MNI152 NLIN 2009b space. BOLD signal time-series matrices are given as .mat files and are viewable in MATLAB. In addition to the matrices, we have also provided a mask in NIfTI-1 format corresponding to voxels in standard space where a BOLD signal could be calculated in >80% of the 77 matrices (NaN mask). The data records derived from this work can be obtained through Zenodo (https://zenodo.org/) and Lead DBS (http://lead-dbs.org/). Crucially, the format of choice can be directly used without further conversion or preprocessing steps with openly available software (http://lead-dbs.org/).