Analysis of human humoral responses in a typhoid vaccine efficacy trial used for SIMON analysis

The VAST dataset contains data from 72 individuals enrolled in the clinical study to evaluate humoral responses in a typhoid vaccine efficacy trial in a controlled human Salmonella Typhi infection model (see original publication: https://doi.org/10.3389/fimmu.2019.02582). Only day 0 (day of the challenge) log-transformed data were used in the SIMON analysis, as described in the publication (https://doi.org/10.1101/2020.08.16.252767). Individuals were vaccinated with either a purified Vi polysaccharide (Vi-PS) vaccine (35 individuals) or the Vi tetanus toxoid conjugate (Vi-TT) vaccine (37 individuals) one month prior to oral challenge with live Salmonella Typhi. Out of 72 individuals, 26 developed an acute typhoid infection following the challenge.