Published August 17, 2020 | Version sub
Dataset Open

Preexisting memory CD4 T cells in naïve individuals confer robust immunity upon vaccination

Authors/Creators

  • 1. University of Antwerp
  • 2. Antwerp University Hospital
  • 3. St. Jude Children's Research Hospital
  • 4. Janssen Research & Development

Description

Data set accompanying the publication "Preexisting memory CD4 T cells in naïve individuals confer robust immunity upon vaccination".

In this study, we utilize high-throughput sequencing to profile the memory CD4 TCRβ repertoire and track vaccine-specific and epitope-specific TCRβ clonotypes following the de novo administration of hepatitis B (HepB) vaccine in healthy HepB-naïve individuals.

The data set is comprised out of the following parts:

  • repTCRb: Folder containing CD4+ TCR repertoire data from volunteers. Some of these samples are also available in ImmuneAccess (https://clients.adaptivebiotech.com/pub/deneuter-2018-cmvserostatus).
  • peptideTCRab: Folder containing peptide-specific or peptide-pool-specific TCR data
  • df_all: Meta and FC data for samples and volunteers
  • freqCD154: CD154-based group definitions
  • groups.csv: Group definitions used for classes

Files

HepB_TCR_FC.zip

Files (274.6 MB)

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