Dataset Open Access
GREEN-DB is a standardized collection of 2.4 million regulatory elements in the human genome. Information on controlled gene(s), tissue(s) and associated phenotype(s) are provided for each element when possible. We also calculated a variation constraint metric (range 0-1) for these regulatory regions and showed that genes controlled by constrained regions are enriched for disease-associated genes and essential genes from mouse knock-out screenings.
The database also includes information from ENCODE TFBS and DNase peaks; ultra-conserved non-coding elements (UCNE), and super-enhancers (dbSuper).
This release includes 2 files:
To annotate a VCF file with information from GREEN-DB you can use our tools GREEN-VARAN (https://github.com/edg1983/GREEN-VARAN).
GREEN-DB is free to use for academic users, please refer to the attached LICENSE file.