Published August 3, 2020
| Version v1
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Coronavirus Treatment: eradicate Coronavirus by blocking replication, counteracting its defense system
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Description
How Treatment works: Coronaviruses reduce p53 protein as defese mechanism, by means an interaction between Sars-unique domain (SUD) and papain-like protease (PLPRO) via E3 ubiquitin ligase RCHY1. P53 is an important factor in downregulation of coronavirus replication, with reduction of Sirtuin 1 SIRT1. Tenovin-1 is a small molecule that inhibits SIRT1 and 2, and activates p53, protecting it against MDM-2 mediated degradation, which involves ubiquitination.
Notes
Created and uploaded on Academia.edu on March 2020.
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HALT_CORONAVIRUS_REPLICATION_LITE.pdf
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(5.6 MB)
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