There is a newer version of this record available.

Preprint Open Access

Coronavirus Treatment: eradicate Coronavirus by blocking replication, counteracting its defense system

Kira Smith

How Treatment works: Coronaviruses reduce p53 protein as defese mechanism, by means an interaction between Sars-unique domain (SUD) and papain-like protease (PLPRO) via E3 ubiquitin ligase RCHY1. P53 is an important factor in downregulation of coronavirus replication, with reduction of Sirtuin 1 SIRT1. Tenovin-1 is a small molecule that inhibits SIRT1 and 2, and activates p53, protecting it against MDM-2 mediated degradation, which involves ubiquitination.

Created and uploaded on Academia.edu on March 2020.
Files (5.6 MB)
Name Size
HALT_CORONAVIRUS_REPLICATION_LITE.pdf
md5:7b2db6f69b9000e25e41db759081a985
5.6 MB Download
1,318
272
views
downloads
All versions This version
Views 1,318457
Downloads 27256
Data volume 357.7 MB313.5 MB
Unique views 1,163432
Unique downloads 22142

Share

Cite as