(Chalcogen)semicarbazones and their cobalt complexes differentiate HL-60 myeloid leukaemia cells and are cytotoxic towards tumor cell lines
Authors/Creators
- 1. Faculty of Chemistry , University of Belgrade , Studentski trg 12-16 , 11000 Belgrade , Serbia
- 2. Department of Chemistry , Sapienza University of Rome , P.le Aldo Moro 5 , 00185 Rome , Italy
- 3. Anatomy Department , Faculty of Medicine and Surgery , University of Malta , Malta
- 4. Institute for Oncology and Radiology of Serbia , Pasterova 14 , 11000 Belgrade , Serbia
- 5. Faculty of Agriculture , University of Belgrade , Nemanjina 6 , 11081 Belgrade , Serbia
Description
Cobalt complexes with semi- and thiosemicarbazones of 8-quinolinecarboxaldehyde have been synthesized and characterized by X-ray diffraction analysis. These novel complexes and a previously synthesized cobalt complex with a selenium-based selenosemicarbazone ligand showed myeloid differentiation activity on all trans retinoic acid resistant HL-60 acute myeloid leukaemia cells. They also showed varying levels of cytotoxicity on five human tumor cell lines: cervix carcinoma cells (HeLa), lung adenocarcinoma cells (A549), colorectal adenocarcinoma cells (LS-174), breast carcinoma cells (MDA-MB-361), and chronic myeloid leukaemia (K562) as well as one normal human cell line: fetal lung fibroblast cells (MRC-5). Leukaemia differentiation was most strongly induced by a metal-free oxygen ligand and the selenium ligand, whilst the latter and the cobalt(II) complex with an oxygen ligand showed the strongest dose-dependent cytotoxic activity. In four out of five investigated tumor cell lines, it was of the same order of magnitude as cisplatin. These best compounds, however, had lower toxicity on non-transformed MRC-5 cells than cisplatin.
Notes
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MD-008-C6MD00501B(3).pdf
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Additional details
Related works
- Is identical to
- PMC6071924 (pmcid)
- 30108695 (PMID)
- 10.1039/c6md00501b (DOI)
Funding
- Ministry of Education, Science and Technological Development
- Pharmacodynamic and pharmacogenomic research of new drugs in the treatment of solid tumors 41026
- Ministry of Education, Science and Technological Development
- Interactions of natural products, their derivatives and coordination compounds with proteins and nucleic acids 172055