ELUCIDATION OF PLAUSIBLE MECHANISMS OF KABASURAKUDINEER FOR COVID-19 BY MOLECULAR DOCKING AGAINST SARS COV-2

The COVID-19 virus main protease (M^pro)and papain like protease (PL^pro) which are the key CoV enzyme, in mediating viral replication and transcription, making it an attractive drug target for this virus. Also, the spike protein also the potential targets for the SARS Cov-2 from which viral entry inhibitors can be designed. The Kabasurakudineer is known to possess the immune modulating and some of the ingredients has anti-viral activity. The docking of phytoconstituents in Kabasurakudineer to the above mentioned three targets shows that the phytoconstituents binds near the hotspot-31 and hotspot-353 residues and key residues of the receptor binding domain of the spike protein. It also inhibits virus main protease (M^pro) and papain like protease (PL^pro) suggested by high binding affinity.

Keywords: Kabasuraku dineer, COVID-19, SARS Cov-2,in-silico, molecular docking, Antiviral