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SUDMEX_TMS: The Mexican dataset of an rTMS clinical trial on cocaine use disorder patients

Garza-Villarreal, Eduardo A.; Fernandez-Lozano, Sofia

Project leader(s)
Garza-Villarreal, Eduardo A.
Project member(s)
Alcala-Lozano, Ruth; Morelos-Santana, Erick; Villicaña, Viviana; Fernandez-Lozano, Sofia; Davalos, Alan

The SUDMEX_TMS dataset is the result of a longitudinal clinical trial of cocaine use disorder patients that were treated with rTMS at 5-Hz on the left dorsolateral prefrontal cortex (lDLPFC) for a 2 week double-blind acute phase and an open-label maintenance phase that included clinical, cognitive and MRI data acquisition. The design was a double-blind placebo-controlled randomized controlled trial with parallel groups (acute phase). The study was done at the National Institute of Psychiatry in Mexico City by PIs Dr. Eduardo A. Garza-Villarreal and Dr. Ruth Alcala-Lozano.

Each patient had more than one clinical and MRI session or time point from baseline (T0), 2 weeks (T1), 3 months (T2), 6 months (T3) and some patients had 12 months (T4). The T14 time point was only for patients in the Sham group who decided to continue the clinical trial with open-label rTMS. The T14 refers to 2 weeks after T1 (4 weeks after T0).

The MRI sequences were: 1) T1-weighted, 2) rsfMRI 10 min, 3) HARDI-DWI multishell (next release).

Here we present different files:

1) derivatives_mrqc.zip - MRIQC: We did a thorough QC of the data.

2) Rmaps.zip - Individual correlations maps for the lDLPFC

3) Zmaps.zip - Individual correlation maps for the lDLPFC and vmPFC converted to Z-score.

4) Submap_PairedTTest.zip - Individual difference maps made in FSL for the Interaction analysis (T1-T0)

 

Raw data: https://github.com/egarza/sudmex_tms_main

For the analysis code and more info refer to the Github folder: https://github.com/egarza/sudmex_tms_main

Derivatives are 320 Gb, hence you need to ask for it if you want to use it.

We would like to thank Alejandra Torres, Daniela Guerrero León, Ernesto Reyes Zamorano,Eden Sanchez Rosas, Hugo García Cantú and Isabel Espinoza Luna for their assistance inconducting the clinical trial. Major thanks to Michael D. Fox and Molly Schineller for providingthe normative connectivity maps from fucidals. We also thank the Laboratorio Nacional deVisualización Científica Avanzada (LAVIS) for the use of their computer cluster and theLaboratorio Nacional de Imagenología por Resonancia Magnética (LANIREM). This study was supported by public funds CONACYT FOSISS No. 0260971 and CONACYT No. 253072. Student scholarships were provided by CONACYT for: Sofia Fernandez-Lozano No. 476284, Alan Davalos No.581492 and Erik Morelos-Santana No. 479345. Cite the preprint: Clinical and functional connectivity outcomes of 5-Hz repeated transcranial magnetic stimulation as an add-on treatment in cocaine use disorder: a double-blind randomized controlled trial. Eduardo A. Garza-Villarreal, Ruth Alcala-Lozano, Sofia Fernandez-Lozano, Erik Morelos-Santana, Alan Davalos, Viviana Villicaña, Sarael Alcauter, Francisco Xavier Castellanos, Jorge J Gonzalez-Olvera medRxiv 2020.07.15.20154708; doi: https://doi.org/10.1101/2020.07.15.20154708
Files (2.6 GB)
Name Size
derivatives_mriqc.zip
md5:d8deeab088655b7cc4194f3fa059a9e0
2.1 GB Download
Rmaps.zip
md5:513352890d3c258bde6aeb0516576741
46.8 MB Download
Submaps_PairedTTest.zip
md5:2607f91511c036a59e0fff9ab513896d
239.4 MB Download
Zmaps.zip
md5:b73e7b5995c7de00b3c3c63a9fd0d14d
201.2 MB Download
  • Garza-Villarreal, Eduardo A., Ruth Alcala-Lozano, Sofia Fernandez-Lozano, Erik Morelos-Santana, Alan Davalos, Vivianaa Villicana, Sarael Alcauter, Francisco Xavier Castellanos, and Jorge J. Gonzalez-Olvera. 2020. "Clinical and Functional Connectivity Outcomes of 5-Hz Repeated Transcranial Magnetic Stimulation as an Add-on Treatment in Cocaine Use Disorder: A Double-Blind Randomized Controlled Trial." medRxiv, July, 2020.07.15.20154708.

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