Other Open Access
The SUDMEX_TMS dataset is the result of a longitudinal clinical trial of cocaine use disorder patients that were treated with rTMS at 5-Hz on the left dorsolateral prefrontal cortex (lDLPFC) for a 2 week double-blind acute phase and an open-label maintenance phase that included clinical, cognitive and MRI data acquisition. The design was a double-blind placebo-controlled randomized controlled trial with parallel groups (acute phase). The study was done at the National Institute of Psychiatry in Mexico City by PIs Dr. Eduardo A. Garza-Villarreal and Dr. Ruth Alcala-Lozano.
Each patient had more than one clinical and MRI session or time point from baseline (T0), 2 weeks (T1), 3 months (T2), 6 months (T3) and some patients had 12 months (T4). The T14 time point was only for patients in the Sham group who decided to continue the clinical trial with open-label rTMS. The T14 refers to 2 weeks after T1 (4 weeks after T0).
The MRI sequences were: 1) T1-weighted, 2) rsfMRI 10 min, 3) HARDI-DWI multishell (next release).
Here we present different files:
1) derivatives_mrqc.zip - MRIQC: We did a thorough QC of the data.
2) Rmaps.zip - Individual correlations maps for the lDLPFC
3) Zmaps.zip - Individual correlation maps for the lDLPFC and vmPFC converted to Z-score.
4) Submap_PairedTTest.zip - Individual difference maps made in FSL for the Interaction analysis (T1-T0)
For the analysis code and more info refer to the Github folder: https://github.com/egarza/sudmex_tms_main
Derivatives are 320 Gb, hence you need to ask for it if you want to use it.
Garza-Villarreal, Eduardo A., Ruth Alcala-Lozano, Sofia Fernandez-Lozano, Erik Morelos-Santana, Alan Davalos, Vivianaa Villicana, Sarael Alcauter, Francisco Xavier Castellanos, and Jorge J. Gonzalez-Olvera. 2020. "Clinical and Functional Connectivity Outcomes of 5-Hz Repeated Transcranial Magnetic Stimulation as an Add-on Treatment in Cocaine Use Disorder: A Double-Blind Randomized Controlled Trial." medRxiv, July, 2020.07.15.20154708.