Published February 29, 2016
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ORF8-Related Genetic Evidence for Chinese Horseshoe Bats as the Source of Human Severe Acute Respiratory Syndrome Coronavirus
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Description
Several lineage B betacoronaviruses termed severe acute respiratory syndrome (SARS)-like CoVs (SL-CoVs) were identified from Rhinolophus bats in China. These viruses are characterized by a set of unique accessory open reading frames (ORFs) that are located between the M and N genes. Among unique accessory ORFs, ORF8 is most hypervariable. In this study, the ORF8s of all SL-CoVs were classified into 3 types, and, for the first time, it was found that very few SL-CoVs from Rhinolophus sinicus have ORF8s that are identical to that of human SARS-CoV. This finding provides new genetic evidence for Chinese horseshoe bats as the source of human SARS-CoV.
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JInfectDis.213.4.579-583.pdf
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Additional details
Biodiversity
- Host of
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(Chaerephon plicata, bat) → (severe acute respiratory syndrome (SARS)–like CoVs, SL-CoVs)(Chaerephon, bat) → (SARS-CoVs)(Rhinolophus affinis, bat) → (severe acute respiratory syndrome (SARS)–like CoVs, SL-CoVs)(Rhinolophus ferrumequinum, bat) → (severe acute respiratory syndrome (SARS)–like CoVs, SL-CoVs)(Rhinolophus macrotis, bat) → (severe acute respiratory syndrome (SARS)–like CoVs, SL-CoVs)(Rhinolophus pusillus, bat) → (severe acute respiratory syndrome (SARS)–like CoVs, SL-CoVs)(Rhinolophus sinicus, Chinese horseshoe bats) → (severe acute respiratory syndrome (SARS)–like CoVs, SL-CoVs)(Rhinolophus sinicus, bat) → (severe acute respiratory syndrome (SARS)–like CoVs, SL-CoVs)(Rhinolophus, bat) → (SARS-CoVs)(Rhinolophus, bat) → (severe acute respiratory syndrome (SARS)–like CoVs, SL-CoVs)