Published April 30, 2015 | Version v1
Journal article Open

Glycosylation of Mouse DPP4 Plays a Role in Inhibiting Middle East Respiratory Syndrome Coronavirus Infection

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Description

Middle East respiratory syndrome coronavirus (MERS-CoV) utilizes dipeptidyl peptidase 4 (DPP4) as an entry receptor. Mouse DPP4 (mDPP4) does not support MERS-CoV entry; however, changes at positions 288 and 330 can confer permissivity. Position 330 changes the charge and glycosylation state of mDPP4. We show that glycosylation is a major factor impacting DPP4 receptor function. These results provide insight into DPP4 species-specific differences impacting MERS-CoV host range and may inform MERS-CoV mouse model development.

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JVirol.89.8.4696-4699.pdf

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Additional details

Biodiversity

Host of
(bat) → (Middle East respiratory syndrome coronavirus, MERS-CoV)
(camels) → (Middle East respiratory syndrome coronavirus, MERS-CoV)
(mouse) → (Middle East respiratory syndrome coronavirus, MERS-CoV)