Published May 2, 2020 | Version PDF
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Cross-Allergy of Sulfonamide-Containing Drugs in Sulfonamide Allergic Patients: A Literature Review and Case Study

Authors/Creators

  • 1. Department of Pharmacy, The First Affiliated Hospital, Jinan University, Guangzhou 510630, Guangdong, China
  • 2. College of Pharmacy, Jinan University, Guangzhou 510630, Guangdong, China

Description

The purpose of this study is to find out whether there are broad cross-reactivity between antibacterial and non-antibacterial sulfonamide agents, the method of the study contained two parts, one is literature research mainly from PubMed database by using the MeSH terms (“Drug name” + allergy); (“Drug name” + hypersensitivity); (“Drug name” + cross-allergenicity) and (“Drug name + cross-reactivity), the search drugs included some commonly seen medication such as carbonic anhydrase inhibitor, COX-2 inhibitor, loop diuretic, sulfonylurea, thiazide and certain antiviral drugs; the other parts of this thesis is to conduct a statistical review, we screen out patients who have a previous allergic history of antimicrobial sulfonamides from hospital medical record system during Jan 1st, 2015 to Dec 31th, 2016, we did a descriptive statistics of general patients medical information, analyze the suspect cases which patients present potential allergic reaction after using non-antimicrobial sulfonamides agents. Result of literature research reveal there are no convincing evidences and research to confirm there are bored allergenicity between non-antimicrobial sulfonamides and antimicrobial sulfonamide in the aspects of chemical structure, immunological study, and large scale population study as well; Result of hospital patient’s statistics found out there are only 3 suspected cases that the patients were having adverse effect during their pharmacotherapy from 506 cases. However, we did not found any strong correlation of broad allergenicity between non-antimicrobial sulfonamides and antimicrobial sulfonamides from these suspected cases. Conclusion: There is minimal evidence of cross-reactivity between the antimicrobial sulfonamides and the non-antimicrobial sulfonamides. However, the non-antimicrobial sulfonamides are rarely implicated in hypersensitivity reactions as well, so it is impossible to say with certainty that cross-reactivity does not occur.

 

 

 

 

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