Fabrication of Gold Nano Drug by Root Aqueous extract of Anacyclus pyrethrum for Pharmacological Applications

The effect of nanoparticles on the natural environment is of growing concerns among environmental scientists and the wider community. Both the fate and behaviour of the nanoparticles in the environment and their effects on the living organisms need to be better understood in order to maintain environmental health and ensure the sustainability of the important nanotechnology industry. Gold nanoparticles are usually synthesized by chemicals which are quite toxic and flammable in nature. This study deals with an environment friendly and biosynthesis process for pharmacological applications of gold nanoparticles, derived from Anacyclus pyrethrum root aqueous extract. The formation and characterisation of AuNPs were confirmed by UV-Vis spectroscopy, Fourier transform infrared spectroscopy (FTIR), scanning electron microscope (SEM) with energy-dispersive spectroscopy (EDX), Dynamic Light Scattering analyses (Particle size and Zeta potential) and X-ray diffraction (XRD). The antimicrobial and anticancer activities were carried out against some human pathogenic strains and HeLa Cancerous cells with different concentrations respectively. The Au nanoparticles inhibited the growth of the microbial pathogens and cancer cells significantly, in a dose and duration dependent manner.