Tyrosinase-Treated Hydroxytyrosol-Enriched Olive Vegetation Waste with Increased Antioxidant Activity Promotes Autophagy and Inhibits the Inflammatory Response in Human THP-1 Monocytes.

-This is the accepted manuscript (post-peer reviewed) of the final paper: "Tyrosinase-Treated Hydroxytyrosol-Enriched Olive Vegetation Waste with Increased Antioxidant Activity Promotes Autophagy and Inhibits the Inflammatory Response in Human THP-1 Monocytes, published in Journal of Agricultural and Food Chemistry, Volume 66, Issue 46, 2018, Pages 12274−12284 https://doi.org/10.1021/acs.jafc.8b0360".

-Meschini R, D'Eliseo D, Filippi S, Bertini L, Bizzarri BM, Botta L, Saladino R, Velotti F (2018) Tyrosinase-Treated Hydroxytyrosol-Enriched Olive Vegetation Waste with Increased Antioxidant Activity Promotes Autophagy and Inhibits the Inflammatory Response in Human THP-1 Monocytes. J Agric Food Chem. 66(46):12274-12284. doi: 10.1021/acs.jafc.8b03630.

ABSTRACT: Treatment of olive vegetation waste with tyrosinase immobilized on multiwalled carbon nanotubes increased the antioxidant activity as a consequence of the conversion of phenols to corresponding catechol derivatives, as evaluated by DPPH, Comet assay, and micronucleus analyses. During this transformation, 4-hydroxyphenethyl alcohol (tyrosol) was quantitatively converted to bioactive 3,4-dihydroxyphenethyl alcohol (hydroxytyrosol). The hydroxytyrosol-enriched olive vegetation waste
also promoted autophagy and inhibited the inflammatory response in human THP-1 monocytes.