Dataset related to the article "High sensitivity C-reactive protein and acute kidney injury in patients wit acute myocardial infarction: a prospective observational study"

This record contains raw data related to the article "High sensitivity C-reactive protein and acute kidney injury in patients wit acute myocardial infarction: a prospective observational study"

Abstract: Background. Accumulating evidence suggests that inflammation plays a key role in acute
kidney injury (AKI) pathogenesis. We explored the relationship between high-sensitivity C-reactive
protein (hs-CRP) and AKI in acute myocardial infarction (AMI). Methods. We prospectively included
2,063 AMI patients in whom hs-CRP was measured at admission. AKI incidence and a clinical
composite of in-hospital death, cardiogenic shock, and acute pulmonary edema were the study
endpoints. Results. Two-hundred-thirty-four (11%) patients developed AKI. hs-CRP levels were
higher in AKI patients (45 87 vs. 16 41 mg/L; p < 0.0001). The incidence and severity of AKI, as well
as the rate of the composite endpoint, increased in parallel with hs-CRP quartiles (p for trend <0.0001
for all comparisons). A significant correlation was found between hs-CRP and the maximal increase
of serum creatinine (R = 0.23; p < 0.0001). The AUC of hs-CRP for AKI prediction was 0.69 (p < 0.001).
At reclassification analysis, addition of hs-CRP allowed to properly reclassify 14% of patients when
added to creatinine and 8% of patients when added to a clinical model. Conclusions. In AMI,
admission hs-CRP is closely associated with AKI development and severity, and with in-hospital
outcomes. Future research should focus on whether prophylactic renal strategies in patients with
high hs-CRP might prevent AKI and improve outcome.