Published May 24, 2020 | Version 1.0
Software Open

TRAIL signalling promotes entosis in colorectal cancer

  • 1. Department of Physiology and Medical Physics, Centre for Systems Medicine, Royal College of Surgeons in Ireland, 123 St. Stephen's Green, Dublin 2, Ireland; Department of Genetics and Bioengineering, Faculty of Engineering, Izmir University of Economics, Balcova, Izmir, Turkey;
  • 2. Department of Physiology and Medical Physics, Centre for Systems Medicine, Royal College of Surgeons in Ireland, 123 St. Stephen's Green, Dublin 2, Ireland;
  • 3. Cellular and Molecular Imaging Core, Royal College of Surgeons in Ireland, D02 YN77 Dublin 2, Ireland;
  • 4. Centre for Cancer Research and Cell Biology, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, 97 Lisburn Road, Belfast, BT9 7BL, UK
  • 5. Molecular Cell Biology Laboratory, Department of Genetics, The Smurfit Institute, Trinity College, Dublin, Ireland;

Description

Datasets and source-code underlying the computational analyses investigating the clinical association among TRAIL signalling, cell-in-cell structures, and colorectal cancer included in the manuscript "TRAIL signalling promotes entosis in colorectal cancer" authored by Emir Bozkurt, Heiko Düssmann, Manuela Salvucci, Brenton L. Cavanagh, Sandra Van Schaeybroeck, Daniel B. Longley, Seamus J. Martin and Jochen H. M. Prehn (submitted 2020, biorxiv preprint).

A pre-built docker image is provided in "prebuilt_docker_image.tar.gz". Files generated by running the code (as described in the ReadMe), including "summary.pdf" (corresponding to Supplementary File 1 of the biorxiv submission), "processed_data/*" and "figures_and_tables" (figure and tables with statistical results) are also provided in "precomputed_files.zip". Additionally, data and code are available in a public BitBucket repository and as myBinder container.

Notes

This work was supported by generous funding from Science Foundation Ireland (14/IA/2582; 16/RI/3740; 16/US/3301) and the Health Research Board (16/US/330; TRA/2007/26).

Files

manuela_s-trail_signalling_promotes_entosis_in_colorectal_cancer-586855793258.zip

Files (818.2 MB)

Name Size Download all
md5:d3dfa6d0ddac61b127f78459e99f76c1
775.1 kB Preview Download
md5:ebbba721b5ac5a9fa819894ce322a627
803.2 MB Download
md5:02224cb14c2a15d8a78907adfdc2309c
14.2 MB Preview Download

Additional details