Preprint Open Access

Efficient molecule discrimination in electron microcopy through an optimized orbital angular momentum sorter

Troiani, Filippo; Rotunno, Enzo; Ravelli, Raimond; Peters, Peter; Karimi, Ebrahim; Grillo, Vincenzo

We consider the problem of discriminating macromolecular structures in an electron microscope, through a specific beam shaping technique. Our approach is based on maximizing the which-molecule information extracted from the state of each electron. To this aim, the optimal observables are derived within the framework of quantum state discrimination, which allows one to fully account from the quantum character of the probe. We simulate the implementation of such optimal observable on a generalized orbital angular momentum (OAM) sorter and benchmark its performance against the best known real space approach.

Files (1.5 MB)
Name Size
1.5 MB Download
All versions This version
Views 4141
Downloads 2020
Data volume 29.4 MB29.4 MB
Unique views 4040
Unique downloads 1919


Cite as