Manuscript for paper on the solution of one instance of the protein orientation problem
- 1. CNR
- 2. FZJ
- 3. FEI
- 4. UMR
- 5. MU
- 6. BOARD
Description
This deliverable is meant to summarise our current conclusions about the cryo-microscopy + OAM sorter experiments. More specifically, we illustrate here how a two-stage OAM sorter allows one to recognise the rotational symmetry as well as the 2D chirality of proteins of interest. Getting information about a protein without actually fully imaging it is one of the main goals of Q-SORT.
This deliverable is one of the partial endpoints of the activities developed so far and takes advantage of task T5.1 (D5.1 and D5.2) and of the sorter itself as developed in WP2. We also use virtual proteins, developed for deliverable D3.3. This deliverable has D5.5, devoted to protein recognition via three-stage or generalized sorter, as its natural continuation.
The deliverable contains 2 parts. The first one is the main manuscript, ideally written for a journal of the Nature publishing Group. The second one is a provisional conclusion that explores the problem of the missing data, the hardware limitations, and improvements, as well as the feasibility of the overall experiments.