Institut za onkologiju i radiologiju Srbije / Institute for Oncology and Radiology of Serbia
Published January 30, 2017 | Version v.1
Journal article Open

Complex formation reactions of gallium(III) and iron(III/II) with l-proline-thiosemicarbazone hybrids: A comparative study

Authors/Creators

  • 1. Institute of Inorganic Chemistry, University of Vienna, Währinger Strasse 42, 1090 Vienna, Austria
  • 2. Department of Inorganic and Analytical Chemistry, University of Szeged, Dóm tér 7, H-6720 Szeged, Hungary and MTA-SZTE Bioinorganic Chemistry Research Group, University of Szeged, Dóm tér 7, H-6720 Szeged, Hungary
  • 3. Department of Inorganic and Analytical Chemistry, University of Szeged, Dóm tér 7, H-6720 Szeged, Hungary
  • 4. Institute for Oncology and Radiology of Serbia, Pasterova 14, 11000 Belgrade, Serbia
  • 5. Department of Chemistry, University of Cape Town, Rondebosch, 7701, Cape Town, South Africa

Description

Three new gallium(III) and iron(III) complexes with l-proline-thiosemicarbazone hybrids, namely [GaCl(l-Pro-FTSC–2H)]·0.7H2O·0.5CH3OH (1·0.7H2O·0.5CH3OH), [GaCl(dm-l-Pro-FTSC–2H)]·0.4H2O (2·0.4H2O) and [FeCl(l-Pro-FTDA–H)]Cl (3) were synthesised and comprehensively characterised by spectroscopic methods (1H, 13C NMR, UV–vis), ESI mass spectrometry and X-ray crystallography. The complexes are soluble in biological media to allow for assaying their antiproliferative activity. The complexes were tested in three human cancer cell lines, namely HeLa, A549 (non-small cell lung cancer), LS174 and nontumorigenic MRC5. Complex formation equilibrium processes of l-Pro-FTSC with gallium(III), iron(II) and iron(II) ions were investigated in solution. The formation of mono-ligand iron(II) and gallium(III) complexes with pentadentate ligands and relatively low aqueous solution stability was found. Between iron(III) and the ligands, a redox reaction takes place via the oxidative cyclisation of the thiosemicarbazone.

Notes

This work was also supported by the Hungarian Research Foundation OTKA project PD103905 and the János Bolyai Research Scholarship of the Hungarian Academy of Sciences. Supplementary material CCDC-1452613, -1452614 and -1452615 contain the supplementary crystallographic data for this paper. These data can be obtained free of charge on application to The Director, CCDC, 12 Union Road, Cambridge CB2 1EZ, UK (email: deposit@ccdc.cam.ac.uk)

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0020-1693 (ISSN)

Funding

FWF Austrian Science Fund
Antiproliferative hybrids and their metal complexes as topoisomerase II P 28223