Cell and tissue response to nanotextured Ti6Al4V and Zr implants using high-speed femtosecond laser-induced periodic surface structures
Authors/Creators
- 1. University of Modena and Reggio Emilia, Reggio Emilia, Italy, NoviNano Lab LLC, Lviv, Ukraine, Department of Photonics, Lviv Polytechnic National University, Lviv, Ukraine
- 2. Sumy State University, Sumy, Ukraine, Osteoplant R&D, Debice, Poland
- 3. Institute of Atomic Physics and Spectroscopy, University of Latvia, Riga, Latvia
- 4. Centro de Química-Física Molecular and IN and IBB, Instituto Superior Técnico, Universidade de Lisboa, Lisbon, Portugal
- 5. Centro de Química-Física Molecular and IN and IBB, Instituto Superior Técnico, Universidade de Lisboa, Lisbon, Portugal, BioISI—Biosystems & Integrative Sciences Institute, Faculty of Sciences, University of Lisboa, 1749-016 Lisboa, Portugal
- 6. Sumy State University, Sumy, Ukraine
- 7. University of Modena and Reggio Emilia, Reggio Emilia, Italy
- 8. Osteoplant R&D, Debice, Poland
Description
In this paper, the effect of femtosecond laser nanotexturing of surfaces of Ti6Al4V and Zr implants on their biological compatibility is presented and discussed. Highly regular and homogeneous nanostructures with sub-micrometer period were imprinted on implant surfaces. Surfaces were morphologically and chemically investigated by SEM and XPS. HDFa cell lines were used for toxicity and cell viability tests, and subcutaneous implantation was applied to characterize tissue response. HDFa proliferation and in vivo experiments evidenced the strong influence of the surface topography compared to the effect of the surface elemental composition (metal or alloy). The effect of protein adsorption from blood plasma on cell proliferation is also discussed.
Files
10.1016j.nano.2019.1020361.pdf
Files
(4.4 MB)
| Name | Size | Download all |
|---|---|---|
|
md5:552e451fd022975ce0451d047a8a2616
|
4.4 MB | Preview Download |
Additional details
Related works
- Is documented by
- Journal article: 10.1016/j.nano.2019.102036 (DOI)