Published March 9, 2020
| Version v1
Dataset
Open
Expansion of UBTR012574 Chemical Series
- 1. University of Toronto, Structural Genomics Consortium
Description
Expansion of the chemical series of UBTR012574 (KD= 10 ± 0.1 µM) by docking analogue compounds from the Enamine REAL database and SciFinder against the USP5 zinc finger ubiquitin-binding domain (ZnF-UBD) to prioritize compound ordering. The binding potency of the ordered compounds against USP5 ZnF-UBD was assessed with a surface plasmon resonance (SPR) assay.
Notes
The SGC is a registered charity (number 1097737) that receives funds from AbbVie, Bayer Pharma AG, Boehringer Ingelheim, Canada Foundation for Innovation, Eshelman Institute for Innovation, Genome Canada through Ontario Genomics Institute [OGI-055], Innovative Medicines Initiative (EU/EFPIA) [ULTRA-DD grant no. 115766], Janssen, Merck KGaA, Darmstadt, Germany, MSD, Novartis Pharma AG, Innovation and Science (MRIS), Pfizer, São Paulo Research Foundation-FAPESP, Takeda, and Wellcome.
Files
1_UBTR012574_analogs_1_zenodo.pdf
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