Physiological parameters for three farm animal species (cattle, sheep, and swine) as the basis for the development of generic physiologically based kinetic models
Creators
- 1. Department of Environmental Science, Institute for Water and Wetland Research, Radboud University Nijmegen, Houtlaan 4, 6525 XZ Nijmegen, The Netherlands
Description
IMPORTANT : PLEASE DISREGARD VERSION 1 OF THIS UPLOAD SINCE IT INCLUDES ERRONEOUS INFORMATION.
This excel file (DOI: 10.5281/zenodo.3433224) provides physiological parameters and their inter-individual variability (mean, coefficient of variation, sample size) for three farm animal species: cattle (Bos taurus), sheep (Ovis aries), and swine (Sus scrofa domesticus). These physiological parameters were estimated based on the results of extensive literature searches and specific experimental data described in Lautz et al., (2020). This file is associated with R codes (DOI: 10.5281/zenodo.3432796) for generic PBK models, partition coefficient Quantitative Structure Activity Relationship (QSAR) models for each farm animal species and parameterisation of the model.
The full data collection and implementation of the models using case studies are described in Lautz et al., 2020 (10.1016/j.toxlet.2019.10.008).
Notes
Files
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Additional details
Related works
- Is supplement to
- Journal article: 10.1016/j.toxlet.2019.10.008 (DOI)
- 10.5281/zenodo.3432796 (DOI)
References
- Leonie Lautz, S. Hoeks, R. Oldenkamp (2019). Development of generic physiologically based kinetic models for three farm animal species, cattle, sheep, and swine. DOI: 10.5281/zenodo.3432796.
- Leonie Lautz (2019). Physiological parameters for three farm animal species (cattle, sheep, and swine) as the basis for the development of generic physiologically based kinetic models. DOI: 10.5281/zenodo.3433224
- Leonie Lautz, Selwyn Hoeks, Rik Oldenkamp, Jan Hendriks, Jean-Lou Dorne, Ad Ragas (2020). Generic physiologically based kinetic modelling for farm animals: Part II. Predicting tissue concentrations of chemicals in swine, cattle, and sheep. Toxicology Letters. 318:50-56
- Leonie Lautz, Jean-Lou Dorne, Rik Oldenkamp, Jan Hendriks, Ad Ragas (2020). Generic physiologically based kinetic modelling for farm animals: Part I. Data collection of physiological parameters in swine, cattle and sheep. Toxicology Letters. 319:95-101.