Dataset related to the article: "CT Perfusion Versus Coronary CT Angiography in Patients With Suspected In-Stent Restenosis or CAD Progression"

This record contains raw data related to the article "CT Perfusion Versus Coronary CT

Angiography in Patients With Suspected

In-Stent Restenosis or CAD Progression"

OBJECTIVES The goal of this study was to assess the diagnostic performance of coronary computed tomography

angiography (CTA) alone, adenosine-stress myocardial perfusion assessed by computed tomography (CTP) alone, and

coronary CTA þ CTP by using a 16-cm Z-axis coverage scanner versus invasive coronary angiography (ICA) and fractional

flow reserve (FFR) as the clinical standard.

BACKGROUND Diagnostic performance of coronary CTA for in-stent restenosis detection is still challenging. Recently,

CTP showed additional diagnostic power over coronary CTA in patients with suspected coronary artery disease. However,

few data are available on CTP performance in patients with previous stent implantation.

METHODS Consecutive stable patients with previous coronary stenting referred for ICA were enrolled. All patients

underwent stress myocardial CTP and rest CTP þ coronary CTA. Invasive FFR was performed during ICA when clinically

indicated. The diagnostic rate and diagnostic accuracy of coronary CTA, CTP, and coronary CTA þ CTP were evaluated in

stent-, territory-, and patient-based analyses.

RESULTS In the 150 enrolled patients (132 men; mean age 65.1 9.1 years), the CTP diagnostic rate was significantly

higher than that of coronary CTA in all analyses (territory based [96.7% vs. 91.1%; p < 0.0001] and patient based [96%

vs. 68%; p < 0.0001]). When ICA was used as gold standard, CTP diagnostic accuracy was significantly higher than that

of coronary CTA in all analyses (territory based [92.1% vs. 85.5%, p < 0.03] and patient based [86.7% vs. 76.7%,

p < 0.03]). The concordant coronary CTA þ CTP assessment exhibited the highest diagnostic accuracy values versus ICA

(95.8%in the territory-based analysis). The diagnostic accuracy of CTP was significantly higher than that of coronary CTA

(75% vs. 30.5%; p < 0.001). The radiation exposure of coronary CTA þ CTP was 4.15 1.5 mSv.

CONCLUSIONS In patients with coronary stents, CTP significantly improved the diagnostic rate and accuracy of coronary

CTA alone compared with both ICA and invasive FFR as gold standard.