Published February 20, 2019 | Version v1
Journal article Open

Carbohydrates@MOFs

Authors/Creators

  • 1. Institute of Physical and Theoretical Chemistry, Graz University of Technology, Austria
  • 2. Department of Chemistry, The University of Adelaide, Australia
  • 3. Institute of Inorganic Chemistry, Graz University of Technology, Austria
  • 4. Australian Centre for Blood Diseases, Monash University, Australia
  • 5. Graz Centre for Electron Microscopy (ZFE), Austria
  • 6. Institute of Organic Chemistry, Graz University of Technology, Austria

Description

MOFs have demonstrated outstanding properties for the protection and controlled release of different bio-entities, from proteins to living cells. Carbohydrates, as pure molecules or as a component of proteins and cells, perform essential biological functions. Thus, an understanding of the role of carbohydrates in the formation of MOF-based bio-composites will facilitate their application to biotechnology and medicine. Here, we investigate the role of carbohydrate molecular weight and chemical functionalization in the formation of carbohydrate@MOF composites. We find that chemical functionalization, such as carboxylation, that leads to an enhancement of metal cation concentration at the surface of the molecule triggers the rapid self-assembly of the MOF material, zeolitic-imidazolate framework 8 (ZIF-8). Furthermore, we determine the encapsulation efficiency and measure the release properties of the carbohydrate under controlled conditions. Our findings show that MOFs can be used to prepare a new class of biocomposites for the delivery of carbohydrate-based therapeutics.

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Additional details

Funding

European Commission
MNEMONIC - Magnetic Enzyme Metal Organic Framework Composites 748649
National Health and Medical Research Council
Delivering nanoparticles to prevent rupture of unstable arterial plaques 1078118
European Commission
POPCRYSTAL - Precisely Oriented Porous Crystalline Films and Patterns 771834
Australian Research Council
Discovery Projects - Grant ID: DP170103531 DP170103531
European Commission
SPRINT - Ultra-versatile Structural PRINTing of amorphous and tuned crystalline matter on multiple substrates 801464
National Health and Medical Research Council
Novel targeted PEG nanoparticles for cancer treatment and monitoring 1098867