Journal article Open Access
Shubham D. Chaudhari, Sachin S. Rane, Prof. (Dr.) Rajesh Y. Chaudhari,Prof. (Dr.) Vijay R. Patil
A simple, robust, precise, UV spectroscopic method has been developed for the simultaneous estimation of Rosuvastatin and Aspirin in bulk and capsule dosage forms. In this paper the estimation of those drugs was carried out by absorbance ratio method. This method is based on measurement of absorption at 239nm and 233nm i.e, λmax of Rosuvastatin and Aspirin respectively. The linearity observed for Rosuvastatin is in the range of 4 to14 μg/ml and for Aspirin is in the range of 20 to 60 μg/ml. The accuracy of method was found to be within the range of 99.62%-99.73% for both Rosuvastatin and Aspirin respectively. The developed method was validated with respect to linearity, accuracy and precision. The method can be employed for estimation of pharmaceutical formulations with no interference from any excipients and diluents. The results were validated as per ICH guidelines.