Dataset Open Access

USP5 ZnF-UBD Co-Crystal Structure with Compound UBTR012574a

Mann, Mandeep; Dong, Aiping; Harding, Rachel; Schapira, Matthieu

Objective: To grow well-diffracting co-crystals of USP5 zinc finger ubiquitin binding domain (ZnF-UBD) to solve the co-crystal structures to determine ligand interactions in the binding pocket and to determine if the predicted binding pose is similar to the experimental binding pose.

Funding acknowledgement: The SGC is a registered charity (number 1097737) that receives funds from AbbVie, Bayer Pharma AG, Boehringer Ingelheim, Canada Foundation for Innovation, Eshelman Institute for Innovation, Genome Canada through Ontario Genomics Institute [OGI-055], Innovative Medicines Initiative (EU/EFPIA) [ULTRA-DD grant no. 115766], Janssen, Merck KGaA, Darmstadt, Germany, MSD, Novartis Pharma AG, Innovation and Science (MRIS), Pfizer, São Paulo Research Foundation-FAPESP, Takeda, and Wellcome.
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1_USP5 ZnFUBD and compound UBTR012574a co-crystal structure.pdf
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RWscreen.xls
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SGCscreen.xls
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UBTR012574_refmac4.pdb
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UBTR012574a_refmac4.mtz
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