Published September 30, 2017
| Version v1
Journal article
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Pessimism is related to Increased Changes over Our DNA
Authors/Creators
- 1. Program of Post-Graduation in Biotechnology/Renorbio, Federal University of Espírito Santo, Alegre, ES, Brazil
- 2. Ph.D.-Departamento de Biologia, Centro de Ciências Exatas, Naturais e da Saúde, Universidade Federal do Espírito Santo.-Alto Universitário, S/N, Caixa Postal 16-29500-000 Alegre, ES, Brasil
Description
116 persons were asked if they were a pessimist about the future. They voluntarily and consensually participated in blood collection for DNA analysis of BDNF exon I promoter gene. DNA was extracted from whole peripheral blood, and after bisulfite conversion, the samples were amplified and qualitatively analyzed. From those who related no pessimism, 26% of the BDNF exon I promoter gene was methylated, while from those who related pessimism, 48% presented the epigenetic perturbation. This is an unprecedentedly finding describing the correlation between this mental status and an epigenetic alteration in this crucial gene for brain maintenance.
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