Journal article Open Access

Nonsteroidal anti-inflammatory drugs– What do we (not) know about them

Radostina Alexandrova; Orlin Alexandrov; Pencho Beykov; Gunay Yetik-Anacak; Jelena Krasilnikova; Gabriela Marinescu; Daniela-Cristina Culita; Crtomir Podlipnik; Chukwuemeka Obinna Ekeh

Nonsteroidal anti-inflammatory drugs (NSAIDs) reversibly inhibit the functioning of cyclooxygenase (COX) – the rate-limiting enzyme in prostaglandin synthesis, and express anti-inflammatory, antipyretic and analgesic effects. NSAIDs are among the most widely used medications in the world and are prescribed for the treatment of various forms of chronic and acute pain, arthritic conditions, rheumatism, fever/pyrexia, gout, etc. Some of them (aspirin) are used also for prevention of secondary cardiovascular disease due to their ability to suppress platelet aggregation. The mini-review summarizes data about mechanism(s) of action, clinical application and side effects/toxicity of these drugs as well as their potential antitumor activity.

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