Published November 4, 2019 | Version v2
Dataset Open

Supplemental Data for "LRRK2 kinase activity regulates lysosomal glucocerebrosidase activity in neurons derived from Parkinson's disease patients"

  • 1. Northwestern University

Description

Sequencing of GBA1 gene (all exons) and LRRK2 (Exon 31 and 41) for all lines included in the manuscript: LRRK2 kinase activity regulates lysosomal glucocerebrosidase in neurons derived from Parkinson's disease patients. We do not observed unexpected point mutations in these genes in non-mutant cell lines. Primers for exon amplification and sequencing of GBA1 were obtained from Stone et al., 2000. PCR conditions were obtained from Lesage et al., 2011, Neumann et al., 2009, and Stone et al., 2000. 

Files

Files (147.4 MB)

Name Size Download all
md5:06820ca3c93905ad42b56a5be53f8dfc
300.6 kB Download
md5:767080c5fa0d93368b44b36fb84304da
300.4 kB Download
md5:a151927440d2b87b08e736eedf88a5e4
305.2 kB Download
md5:fddd2e8bb29d6d4609bd0657e42ec83f
282.1 kB Download
md5:c1b98eef610a9471bcef59c6cc9e5b65
294.6 kB Download
md5:e3409d9ab34313bb3c07b1c99d27d728
299.4 kB Download
md5:45630bbc9a4a176e9f8f41c66e700dc1
305.2 kB Download
md5:e7b3d8bca3810b530d41ab3f19fd9819
306.2 kB Download
md5:3abac80c0b0b6b54f3ccbbf3b6f22607
308.8 kB Download
md5:e192a1b2f1162c57927ccc2a8827ab43
304.7 kB Download
md5:4c8b387918a7e8a3f5134204207aaab6
299.9 kB Download
md5:9ff7545e1a5efc0e755ab886ec842228
295.1 kB Download
md5:a3e8d8dc3108bc521bc37f95cb248f5e
297.1 kB Download
md5:c989ef8aea790b8eacd290f8864e2886
291.5 kB Download
md5:d36f31b6e095ea354506085091043489
286.4 kB Download
md5:7f36c31e2cecdef741aa391aaa1b05e5
289.9 kB Download
md5:87a87666b1e21ada8f6c6913f34a24b1
293.5 kB Download
md5:eb1c8f16bb641da4eb3288e1b9b67f97
302.6 kB Download
md5:0af12c06b847257436b7563aa8fcab6c
299.8 kB Download
md5:1d31275ec8c17194ed07356103bb7986
280.4 kB Download
md5:646027d3b3960c9b66fa0aa0a7fc82fd
289.8 kB Download
md5:07f9b1ca370d3c17d3da20a3d9c974d4
301.9 kB Download
md5:6e9e0b098332646db5173c04783b714c
295.2 kB Download
md5:17fc34f75acf29f5bb38068e76866f0f
305.2 kB Download
md5:5ba602a55a40683f803c6bbe2f97b517
307.5 kB Download
md5:400579cf4a18eacffe46c0cd59cd3163
302.0 kB Download
md5:363adda26adea60cf0b77a1c0a77d2d4
298.7 kB Download
md5:4d7a23ef9566c87196a193952dd92849
294.3 kB Download
md5:5136777b12557fafd182ad8850f670a0
295.5 kB Download
md5:755a1f973b82a82773a9430aa8721e5d
285.0 kB Download
md5:bfcef98676b01db62996594a60977165
293.6 kB Download
md5:00a7ac84d9a451aa9c559a767122d299
302.8 kB Download
md5:3ac8b9f318ce62962efb973041537af1
288.4 kB Download
md5:6b8716b1b97184c86d3f49e65ffbc735
298.3 kB Download
md5:d67f89516681a4826c49ff893977db31
302.3 kB Download
md5:3890acfc03500e36bb616b4da2352c79
303.9 kB Download
md5:dc79178fb25957d8ae27143bab52ea3e
275.7 kB Download
md5:1fa510a7c4b350964b13a6012c0c3300
283.5 kB Download
md5:a2806a9916140268bf6db80d2cc0d6c3
299.4 kB Download
md5:aeb0a37a93b6ca914c702ca5c345e08a
294.8 kB Download
md5:8f604f5239089c65b9530b18de74cf23
301.2 kB Download
md5:a3e5a8cff9852c99662ede5f8f5350a5
303.9 kB Download
md5:2459865bc8bc9759605422985fd3c6d3
301.8 kB Download
md5:3c20c5842120c947d5fe4cf192acaaa6
297.3 kB Download
md5:6a16c294f01013e3555007f759191c14
297.1 kB Download
md5:e8d5654c536513ea68ff48a449f13674
292.3 kB Download
md5:e1919bd6e17258c9e399eebf2e77a052
295.3 kB Download
md5:1725a4acbdc80706b1d531ea5a6db355
287.1 kB Download
md5:f7e39a4907335b86b362d958dfe73a74
261.8 kB Download
md5:153d471f2d07339176bc0a1ac2d87a3c
291.8 kB Download
md5:da8b646f742dfeed750f5ea025f3e501
285.4 kB Download
md5:e2742eaffa22a52aa72a07098b835a03
305.7 kB Download
md5:716a5533f6c4e82ee02c88d1fda166c7
303.8 kB Download
md5:4714b69a724ac5129b3113473173414c
310.1 kB Download
md5:203a577bdf92f0c043f8c1944e69f243
284.1 kB Download
md5:6ee495c9fe98181d404726e37900ec99
290.3 kB Download
md5:7ef40fd27cde1ad3bb81f68205f0700a
306.7 kB Download
md5:0c4633b94f1c894c4117f60b98082c88
311.8 kB Download
md5:848354e55246bf0e12deb9814e87be8c
309.0 kB Download
md5:0cfcc6faa790558452674a5e191e0c5f
305.7 kB Download
md5:d068911d26884859568ac9526eaca2b5
304.9 kB Download
md5:be6605c8144b2ca472a6efeaae6f1b7e
302.4 kB Download
md5:ebf29b415fdd5db4d7afcc0211275c3c
294.6 kB Download
md5:e1bc5ed362908fecbaccb1910ceadf38
302.1 kB Download
md5:7e47088acd54b573225b5dba7049bb2f
225.3 kB Download
md5:d0cbe3c53ebda82894bbd3283505beb6
203.9 kB Download
md5:97f65695a1595d71184d5c914fa0e954
308.3 kB Download
md5:a931f2f5d76ce50388b0e4579b71b6b3
287.0 kB Download
md5:71d0e0648bb5922fabee3556e3b6bdd1
294.0 kB Download
md5:98af7ee3811aeb3025b9f755715dc77b
310.1 kB Download
md5:ba584d6cf2141cd0771334379783a5ec
311.6 kB Download
md5:571ebfe518a6ec93d5d2413823599c0e
312.5 kB Download
md5:6627c65a8a255ead8c2d8ca84d6b2905
300.3 kB Download
md5:1e6bf1a47ab31da6d4c45c121757c0d7
305.3 kB Download
md5:00fbdc65e67559c016b11cbf49a10cb1
302.5 kB Download
md5:8e7fcbeec3f44833295fdbabd9439d9d
285.9 kB Download
md5:f52eb267f12c2b76f450bf58dc52512b
285.3 kB Download
md5:0446120d6eaceee4edeeff515ea1ccc9
295.5 kB Download
md5:a2942ebd00ce99849cfabedef1396bbc
203.9 kB Download
md5:2fc84f15ee9c41958a13868784d82eaf
305.9 kB Download
md5:fb39e9b5c0fd64a9daef787a5c09e19e
316.9 kB Download
md5:f2cbf4cc34de1d02829de24be02078e1
307.9 kB Download
md5:21b2e21db9e2d8b1f31c078edcdc053c
301.9 kB Download
md5:768f92d161f0e4fcfc1233d9b3495b3d
309.6 kB Download
md5:7ecd4903819ed19f8cb7f89ae9d63bd3
315.1 kB Download
md5:4da9914dac07f42ba8dc20af901867ac
311.0 kB Download
md5:99e677ec9059d19749f69c6be07e6c6a
308.9 kB Download
md5:6ecf917a4bd25bd04f6134d929502e0a
310.0 kB Download
md5:6b20335d11ad8426ba92e031e70716c5
321.2 kB Download
md5:2e571ef53496b4ea2f9d5cbd1d44ef32
309.3 kB Download
md5:105dd7f2fe0d4e8a52555b17f0041b9d
310.2 kB Download
md5:8c6e564ea60826081af491a98023f3d0
305.5 kB Download
md5:75b74eb44b558f25a3c8c656ad5598da
309.7 kB Download
md5:f382bf80fd604909ffe29e111d5ede43
303.9 kB Download
md5:8afbe97f9e352412fa5a1e560bd0f747
319.7 kB Download
md5:f480ae26d209405d035732d9220af327
309.0 kB Download
md5:dc2291d7385d9ea422b4f3912938de75
306.3 kB Download
md5:9ca6efdbeaa26f136c3a2217dc2845cd
313.7 kB Download
md5:aa6c4e5714d3bb9f492227e28cf1fd67
311.6 kB Download
md5:00870e4061be41c7eebaee2a48dfb67b
311.4 kB Download
md5:bac8e5cdbacfec0d60cf2e41c81be815
305.8 kB Download
md5:cac40dc419075dd5dd834a7212a88223
308.1 kB Download
md5:ed7d18ea0962238db774cab4d7cdc8e7
312.0 kB Download
md5:0e479954ed7e2262bf95e7112c44aca4
309.4 kB Download
md5:89dc5a572fc095e3d6769486fefeaea9
304.2 kB Download
md5:eb600c7d4b51a81b0f54e48fb0e6089a
206.2 kB Download
md5:e66e882404c9fbf2b483b887aa5b1a57
308.9 kB Download
md5:c9c8ee605a3f5124ca827fa3e221a159
308.2 kB Download
md5:5cb70d16fb603636320d0203275765ae
203.9 kB Download
md5:0adb8bbc39a4ed8f6ea0d78a6d7fa134
306.7 kB Download
md5:5cb70d16fb603636320d0203275765ae
203.9 kB Download
md5:bc2b767c435089e3aaab573a713229a5
309.1 kB Download
md5:55fd1a5832298c1be9335ddee6c7ab5f
290.8 kB Download
md5:015e4e85f5e7d3ec9c46acaddeac8f47
299.0 kB Download
md5:a00f5251771b19c2e5ff46989b3509a4
310.5 kB Download
md5:9e3de652a43a5aa092ef7709716e1330
318.9 kB Download
md5:cc6f3423111906c0b157952734fe30ed
316.7 kB Download
md5:fd999074922491dcd6e99f7239693e3a
307.2 kB Download
md5:cb2c03be9e1394c02dcb09f37e32cee9
307.6 kB Download
md5:1e7f2838ef51853861afe31e20830dab
308.7 kB Download
md5:58df1f0c419a2f0e07f99c6c1ee7d157
289.2 kB Download
md5:15a808fbf528e469f2d8683bb7c9ab82
293.6 kB Download
md5:3bd49c838229805d33a2f63ce8ba1936
291.6 kB Download
md5:18571ddb108e757f53f1036a65e970d1
290.3 kB Download
md5:b5b9ac9f74bfffcb6bc667294cbb953f
311.3 kB Download
md5:9d4378488a2f33421c81dbb808cb34c8
312.3 kB Download
md5:af2b85c83ea7451922fd559c41950bfc
303.1 kB Download
md5:a390129f7341d2e3b4606b8db3b0b037
279.7 kB Download
md5:fdd408d4d573d3379fb2ca2f695d6d58
307.5 kB Download
md5:18dc35f9e591d17c168476f289b5172e
308.1 kB Download
md5:58df1f0c419a2f0e07f99c6c1ee7d157
289.2 kB Download
md5:25864dbc4757bbaa55cdcd675c0df7ba
292.9 kB Download
md5:3ae23d4b7ee64daea04ca861e62128ee
311.5 kB Download
md5:f643195167c3ae24231c06b7bb4f4de9
225.2 kB Download
md5:1b0142f82ef9defa08ee7382ca7cf68c
211.7 kB Download
md5:f643195167c3ae24231c06b7bb4f4de9
225.2 kB Download
md5:a8bc0b75118e4f9b81294734276006e9
203.9 kB Download
md5:a043c5c95ca763d21aa3c8cb2506f9a5
305.7 kB Download
md5:dca39ae8ce1066ed35e036b003f48788
286.3 kB Download
md5:54a831b361483ca6d7076b153af7ae82
289.3 kB Download
md5:64fbc922cf61c2bed83c7069b5d7aaa1
304.4 kB Download
md5:9fcb807ebada92920ea5105b499035d2
307.6 kB Download
md5:529340d3e853f9db9041e4906010b9f4
306.2 kB Download
md5:5480a6f2994a80c80bd13a598d2669db
305.1 kB Download
md5:87b08e7d704dda7f01aeb8bae717bbd2
302.9 kB Download
md5:5d7bd0d34614b4e2b373374bd9cd519f
309.4 kB Download
md5:a06155bc49b10b5ef77e2d46d8945638
281.3 kB Download
md5:02d84b5c50cd519b6ca99fa7cb289090
282.0 kB Download
md5:f6220cacb3abf086b6dce11367a83ab5
286.6 kB Download
md5:6b8716b1b97184c86d3f49e65ffbc735
298.3 kB Download
md5:3890acfc03500e36bb616b4da2352c79
303.9 kB Download
md5:8c6eaa9a078486c3252231dcbd6d347e
308.9 kB Download
md5:04d053efd1639dd2884bd1a0306d7d30
281.9 kB Download
md5:14562fde1c2c8d0db2b2e556869a772a
294.2 kB Download
md5:63ff1475aefc2bed682d5c2782cab743
310.3 kB Download
md5:8afdff15196266f7cdf70fa66a9aa04e
314.5 kB Download
md5:a3328d3e14c50960908302689a0c2bca
298.7 kB Download
md5:fdd6effedd0ff61776e7845ac5201239
303.6 kB Download
md5:3e658252ed8897e1d4a0ac8e1a52be76
302.8 kB Download
md5:2741c4fa8083175e48d229705b96f7c6
306.2 kB Download
md5:2503699fc0e0775f072b8a4870a72a8c
282.9 kB Download
md5:8b2731c0d5a88f136a10842093d6b072
309.7 kB Download
md5:089319047475e9adc514c30908a5e207
285.8 kB Download
md5:4223921b294ce614f545189df36933ac
291.1 kB Download
md5:7254131a9fbbc5384e1d09cd31a929e6
309.8 kB Download
md5:b1ca220f11b28e7dd47fa002807e75e6
308.9 kB Download
md5:96c2a9c60d99cadfa10df9521b54e545
304.2 kB Download
md5:1271b1a188274e1831ee056c82c1fa0b
304.0 kB Download
md5:1e0b618358305ae1b5756e68e2c68788
306.4 kB Download
md5:2cd63783303678ef5499c3aae8c79079
286.7 kB Download
md5:b9e432f2523cdb3d2566f9a81e0d5674
282.9 kB Download
md5:0d79be84a150ecb47e16853ec52cd3e6
225.4 kB Download
md5:eb7c745011a35c9db235f3d74edc125f
242.0 kB Download
md5:fc92441ce96010cdd71f11d445d46b5e
291.3 kB Download
md5:8d5933f60ead70392abfc811310c0b90
287.2 kB Download
md5:c5831627c6693b1aa556e52109c113ee
288.1 kB Download
md5:40fdfe2025b5c13fadd3bfd11a5dd1c0
295.4 kB Download
md5:beaa84e58f6788ae8f27463e4856dfee
297.2 kB Download
md5:d4d845d7d5334a8af0a630931a796ed0
289.6 kB Download
md5:327fb0cfea87db66f68e1485f8051bbf
286.5 kB Download
md5:26f7fa8a5760ae2fdd7db7fe488cb62e
294.0 kB Download
md5:4758446f506dc2ee342ee651e7779e5b
288.0 kB Download
md5:4c56992544ef18246d99b93d15c99c30
283.6 kB Download
md5:9717659fa145432ffb8b2715c0fe8caa
286.6 kB Download
md5:4c2de1ec4a88606f80725b35b01ec7d8
285.1 kB Download
md5:0a7a109e133f18f4e52c0ba46f1897ce
225.3 kB Download
md5:c2de7c6c88983b7fd4cb9d0a074df38a
203.8 kB Download
md5:2717252e61c87f62bbeac61734075ca5
291.7 kB Download
md5:8a7efb606ce21569f1d467bb4d313029
287.5 kB Download
md5:fbfcfb6a751df66775e1149df59c0188
291.9 kB Download
md5:4a2bdaab4039f1e066058330c1cf80dd
293.5 kB Download
md5:e2f152bb71640ba089c428ff64f8d553
293.5 kB Download
md5:f5d77bc2d0927231f95172f294b2eae2
225.4 kB Download
md5:3f4af8dbd03e698dc13038f07768bb46
287.4 kB Download
md5:2556d5b87f9d89206e826772cdf58c86
203.9 kB Download
md5:a1162e63d45f23db547ecaba33c996f6
290.6 kB Download
md5:c7a49ec347612202d4d95fd4d74a57c5
298.6 kB Download
md5:b3fdd676635410c86f11a48a6cebf2db
293.3 kB Download
md5:f12a669d1522681384b6959473c549f3
286.9 kB Download
md5:12da8834af10caf51685973a941dc158
287.2 kB Download
md5:e353bba5135bf07edd1ff3e2c39329ad
88.9 MB Download