Institut za onkologiju i radiologiju Srbije / Institute for Oncology and Radiology of Serbia
Published March 26, 2017 | Version v.1
Journal article Open

Cytotoxic and Antimicrobial Activities of Cantharellus cibarius Fr. (Cantarellaceae)

Authors/Creators

  • 1. Department of Pharmacognosy, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia
  • 2. Institute for Oncology and Radiology of Serbia, Belgrade, Serbia
  • 3. Department of Organic Chemistry, Faculty of Technology, University of Niš, Leskovac, Serbia.
  • 4. Center for Food Analysis, Belgrade, Serbia.
  • 5. Department of Microbiology and Immunology, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia
  • 6. Department of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy

Description

Antibacterial and cytotoxic activities of cyclohexane, dichloromethane, methanol, and aqueous
extracts of Cantharellus cibarius were tested. Broth microdilution assay was performed against
10 bacterial strains (Staphylococcus aureus, S. epidermidis, Micrococcus luteus, Bacillus
subtilis, Enterococcus feacalis, Escherichia coli, Klebsiella pneumoniae, Pseudomonas
aeruginosa, Salmonella abony), with emphasis on Helicobacter pylori. Methanol extract was the
most active against H. pylori strains with minimal inhibitory concentration values between 4 and
32 μg/mL. All extracts were active against antibiotic-resistant H. pylori. Methanol and aqueous
extracts had no cytotoxicity against tested cell lines, whereas cyclohexane and dichloromethane
extracts were active against HeLa and N87 cells, but also against healthy MRC-5 cells (IC50
39.26 ±1.24–134.79 ±0.01 μg/mL). The tested aqueous extracts have shown 68% of angiotensin-converting enzyme inhibitory activity in doses of 1.25 mg/mL. Chemical analysis has shown the
presence of linoleic, cis-vaccenic, and oleic acids, sterols, ß-glucans, and polyphenolic
compounds.

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Additional details

Related works

Is identical to
Journal article: 28613963 (PMID)
Is part of
1096-620X (ISSN)

Funding

Ministry of Education, Science and Technological Development
Plants and synthetic bioactive products of new generation 34012
Ministry of Education, Science and Technological Development
Investigation on the medicinal plants: morphological, chemical and pharmacological characterisation 173021