EVALUATION OF ANTI-DIABETIC AND ANTI-HYPERLIPIDEMEDIC ACTIVITY OF CRATAEVA NURVALA (BUCH-HAM.) LEAVES AND ROOT BARK METHANOLIC AND AQUEOUS EXTRACT

Diabetes and Hyperlipidemic disease effects many people around the world and their development is a result of the high glucose level and high cholesterol levelin many of the people effecting with cardiac arrest and myocardial infarction. The presence of various phytoconstituent such as glycosides, tannins, flavonoids, saponins, alkaloids, steroids, and triterpeniods were evident in CNLE and CNRBE. The presence study was undertaken to investigate the anti diabetic and anti hyperlipidemic effect of Crataeva nurvala leaves and Root bark of CNLE and CNRBE (250 and 500mg /kg, b.w , p.o) respectively following 7- days treatment in streptozotocin induced in albino wistar mice and 31 days treatment in Triton X-100 induced model in albino wistar rats. Metformin HCL 10mg/kg was taken as standard and Streptozotocin and Atrovastatin 10mg/kg was taken standard Triton X-100 was taken as inducers as drugs. The Diabetic effect of the extract is attributed to have lowered the glucose level and Hyperlipidemic effect of extract is attributed to have lower cholesterol level in histological studies. The anti diabetic and hyperlipidemic activity is recognized by a reduction in glucose and cholesterol level.