Dataset Open Access

USP5 Ubiquitin-Rhodamine110 Catalytic Activity Assay

Mann, Mandeep; Smith, Leanna; Harding, Rachel; Schapira, Matthieu

A ubiquitin-rhodamine110 assay was used to determine if ZnF-UBD ligands antagonize USP5 deubiquitinase (DUB) activity 

Funding acknowledgement: The SGC is a registered charity (number 1097737) that receives funds from AbbVie, Bayer Pharma AG, Boehringer Ingelheim, Canada Foundation for Innovation, Eshelman Institute for Innovation, Genome Canada through Ontario Genomics Institute [OGI-055], Innovative Medicines Initiative (EU/EFPIA) [ULTRA-DD grant no. 115766], Janssen, Merck KGaA, Darmstadt, Germany, MSD, Novartis Pharma AG, Innovation and Science (MRIS), Pfizer, São Paulo Research Foundation-FAPESP, Takeda, and Wellcome.
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