Bayesian network analysis of plasma microRNA sequencing data in patients with venous thrombosis

This dataset contains the results of 2 related analyses, described in "Bayesian network analysis of plasma microRNA sequencing data in patients with venous thrombosis" (European Heart Journal Supplements, OUP). Link to the article: https://www.hal.inserm.fr/inserm-02310241

1) In the directory "miRNAs_MARTHA_GWAS" : GWAS summary statistics for 162 circulating miRNAs in 344 VTE patients from the MARTHA cohort.

Header for each summary file:

Trait: miRNA id
chr: Chromosome
pos.hg19: Position of the variant in hg19/GRCh37 coordinates
SNP: rsid
A1: Reference allele on the forward strand
A2: Alternate allele on the forward strand
freq_A1: Frequency of reference allele
rsqr: Imputation quality defined by MACH
beta_A1: Estimated effect size (beta regression coefficient) of reference allele
se_A1: Estimated standard error of beta
p: p-value (significance of estimated beta)
z.score: Z-score

2) In the directory "meta_analysis": Random effect meta-analysis combining the results of our GWAS on the MARTHA cohort, and the results from a similar analysis conducted by Nikpay et al. (doi: 10.1093/cvr/cvz030). Summary statistics of 142 microRNAs, common to both datasets, were processed (and combine 1054 samples).

Header for each summary file:

chr: Chromosome
pos.hg19: Position of the variant in hg19/GRCh37 coordinates
SNP: rsid
A1: Reference allele on the forward strand
A2: Alternate allele on the forward strand
N: Sample size
Q: Cochran's heterogeneity statistic
Q.p: p-value of Cochran's Q
beta_A1: Estimated effect size (beta regression coefficient) of reference allele
se_A1: Estimated standard error of beta
p: p-value (significance of estimated beta)