Journal article Open Access
Suresh Kumar .P*, Madhva Rao .S .Jagannath Patro.V, Vanitha .S .Bindhu .T, Sunitha .CH
The aim of the present study was to develop Extended release formulation of Baclofen to maintain constant therapeutic levels of the drug for over 12 hrs. Guar gum, sodium alginate and carbopol 940 were employed as polymers. All the formulations were passed various physicochemical evaluation parameters and they were found to be within limits. Whereas from the dissolution studies it was evident that the formulation (F6) showed better and desired drug release pattern i.e., 96.32% in 12 hours. It contains the sodium alginate as Extended release material. It followed Zero order release kinetics mechanism.