Published July 31, 2019
| Version v1
Dataset
Open
Prioritizing Commercial Analogues of Previous USP5 ZnF-UBD Hits
Creators
- 1. University of Toronto, Structural Genomics Consortium
Description
Expansion of the chemical series of previous hits of USP5 zinc finger ubiquitin binding domain (ZnF-UBD) by docking commercially available chemical analogs and prioritizing chemical analogues to exploit new interactions in the binding pocket of USP5 ZnF-UBD
Notes
Funding Acknowledgment: The SGC is a registered charity (number 1097737) that receives funds from AbbVie, Bayer Pharma AG, Boehringer Ingelheim, Canada Foundation for Innovation, Eshelman Institute for Innovation, Genome Canada through Ontario Genomics Institute [OGI-055], Innovative Medicines Initiative (EU/EFPIA) [ULTRA-DD grant no. 115766], Janssen, Merck KGaA, Darmstadt, Germany, MSD, Novartis Pharma AG,Innovation and Science (MRIS), Pfizer, São Paulo Research Foundation-FAPESP, Takeda, and Wellcome.
Files
1_dockinganalogues_zenodo.pdf
Files
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