Institut za onkologiju i radiologiju Srbije / Institute for Oncology and Radiology of Serbia
Published November 27, 2017 | Version v.1
Journal article Open

Synthesis, characterization and crystal structures of two pentagonal-bipyramidal Fe(III) complexes with dihydrazone of 2,6acetylpyridine and Girard's T reagent. Anticancer properties of various metal complexes of the same ligand

Creators

  • 1. Faculty of Chemistry, University of Belgrade, Studentski trg 12-16, Belgrade, Serbia
  • 2. Faculty of Chemistry and Chemical Technology, University of Ljubljana, Večna pot 113, 1000 Ljubljana, Slovenia
  • 3. Institute of Oncology and Radiology of Serbia, Pasterova 14, 11000 Belgrade, Serbia.
  • 4. Institute of Chemistry, Technology and Metallurgy, University of Belgrade, Njegoševa 12, P.O. Box 815, 11000 Belgrade, Serbia.
  • 5. Institute of Chemistry, Technology and Metallurgy, University of Belgrade, Njegoševa 12, P.O. Box 815, 11000 Belgrade, Serbia
  • 6. Faculty of Technical Sciences, University of Priština, Knjaza Milosa 7, Kosovska Mitrovica, Serbia

Description

In this work synthesis, characterization and crystal structures of two isothiocyanato Fe(III) complexes with 2,2'-[2,6-pyridinediylbis(ethylidyne-1-hydrazinyl-2-ylidene)]bis[N,N,N-trimethyl-2-oxoethanaminium] dichloride (H2LCl2) ligand, with composition [FeL(NCS)2]SCN·2H2O and [FeL(NCS)2]2[Fe(H2O)(NCS)5]·4H2O, has been reported. Both iron(III) complexes possess the same pentagonal-bipyramidal complex cation, while the nature of their anions depends on mole ratio of NH4SCN and FeCl3·6H2O used in reaction. Cytotoxic activity of new Fe(III) complexes, as well as of previously synthesized isothiocyanato Co(II), Ni(II), Mn(II), Zn(II) and Cd(II) complexes with the same ligand, was tested against five human cancer cell lines (HeLa, MDA-MB-453, K562, LS174 and A549) and normal cell line MRC-5. The best activity was observed in the case of Fe(III), Co(II) and Cd(II) complexes. The investigation of potential of these complexes to induce HeLa and K562 cell cycle perturbations was also evaluated. Mechanism of cell death mode was elucidated on the basis of morphological changes of HeLa cells as well as identification of target caspases. It was established that DNA damage could be responsible for the activity of Fe(III) and Co(II) complexes.

SYNOPSIS: Pentagonal-bipyramidal Fe(III) complexes with dihydrazone of 2,6-diacetylpyridine and Girard's T reagent have been synthesized and characterized. Cytotoxic activity of Fe(III) complexes and Co(II), Ni(II), Mn(II), Zn(II) and Cd(II) complexes with the same ligand was tested. The best activity was observed in the case of Fe(III), Co(II) and Cd(II) complexes.

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Synthesis, characterization and crystal structures of two pentagonal bipyramidal Fe(III) complexes with dihydrazone of 2,6-diacetylpyridine and Girard's T reagent....pdf

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Additional details

Related works

Has part
0162-0134 (ISSN)
1873-3344 (ISSN)
Is identical to
2867-2143 (ISSN)

Funding

Biological response modifiers in physiological and pathological conditions 175011
Ministry of Education, Science and Technological Development
Interactions of natural products, their derivatives and coordination compounds with proteins and nucleic acids 172055
Ministry of Education, Science and Technological Development