FABRICATION AND EVALUATION OF SIMVASTATIN NANO SPONGES FOR ORAL DELIVERY

The present work is to enhance bioavailability of drugs from BGS class II drugs like simvastatin by incorporating them in Nano sized drug delivery. Nano sponges are mesh like structures with a size range of below 1µm. Due to their small size and porous structure they can easily bind poorly soluble drugs, which leads to improve the solubility and ultimately the bioavailability of the same. Nanosponges is water soluble. This does not mean the molecules chemically break up in water, but it means that Nanosponges particles can mix with water and use it as transport fluid, for example to be injected. So, in theory Nanosponges has several advantages over other delivery methods. In this work poorly soluble drug i.e. simvastatin is formulated in Nanosponges for solubility enhancement.it is formulated in four batches by using Pluronic F68 and PVA.in this article preparation and evaluation of Nanosponges is described as per obtained results.