POTENCY OF BELIMBING WULUH (AVERRHOA BILIMBI) AS ANTIOXIDANT AND TYROSINASE INHIBITOR FOR SKIN WHITENING PRODUCTS
Authors/Creators
- 1. 1 Sekolah Tinggi Ilmu Farmasi"Yayasan Pharmasi Semarang", Jl. Letjend sarwo edie wibowo Km 1 Plamongansari Semarang, INDONESIA. 2 Ahmad Dahlan University, Jalan Prof. Dr. Soepomo, S.H. Janturan Yogyakarta, INDONESIA. 3 Gadjah Mada University, Jl. Sekip Utara Yogyakarta, INDONESIA.
Description
ABSTRACT
Hyperpigmentation is an event that occurs due to excessive production of skin pigments, where the presence of melanin. Belimbing wuluh as Indonesian plant is rich compounds that function as antioxidants and tyrosinase inhibitor. The aim this research to test the potency of belimbing wuluh extracts as antioxidant and tyrosinase inhibitors for active ingredients whitening for skin. The method used in the study is experimental laboratory with some testing among others test for antioxidant activity with DPPH. Rutin as a standard for antioxidant activity. Tyrosinase inhibitor activity using tyrosinase from mushroom as enzym and L-tyrosine as a substrate with kojic acid as a standard. The IC50 value of antioxidant activity of belimbing wuluh fruits extract is 2331.69±339.09 mg/ml and 320.76±79.54 mg/ml from leaves extract. The IC50 value of antioxidant activity greater than rutin 5.92 mg/ml. Tyrosinase inhibitor activity can be seen from IC50 values is 186.85±9.37 mg/ml from fruits extract and 150.57±6.25 mg/ml from leaves extract. The IC50 value of tyrosinase inhibitor greater than kojic acid 16.68 mg/ml. Our findings showed that belimbing wuluh leaves extract better than fruits extract. These results suggest that belimbing wuluh is a natural ingredient that has potential to be used in halal skin whitening product.
KEYWORDS: Antioxidant, Belimbing Wuluh, Tyrosinase Inhibitor.