PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity

Introduction

These are the Summary Level-data as presented in:

"PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity". Nature Communications volume 9, Article number: 2904 (2018) doi: 10.1038/s41467-018-04766-9 

If you use these data please cite the corresponding manuscript, which can be downloaded here: https://www.nature.com/articles/s41467-018-04766-9. When you have any questions or comments regarding this study or these files, please contact me via:

Jessica van Setten, PhD | Department of Cardiology, University Medical Center Utrecht, Utrecht University | j.vansetten [at] umcutrecht [dot] nl

Files and description

The file PR_interval_July2018_summary_results.txt is gzipped and contains the PR interval GWAS meta-analysis summary results of 92,000 European samples. The imputation reference panel used for most studies was HapMap2 (please note: hg18, build36). 

• SNP - variantID (rsID).
• CHR - chromosome numbers [1-22 and X].
• POS - base pair position, hg18 / build36.
• CODED_ALLELE - coded allele, i.e. the effect allele, as represented (and harmonized) across cohorts. Note that this is not necessarily the minor allele.
• NON_CODED_ALLELE - the other allele, i.e. the non-effect allele.
• CODED_ALLELE_FREQ - coded allele frequency, i.e. the effect allele frequency. Note that this is not necessarily the minor allele frequency.
• BETA_FIXED - beta from the fixed-effects model.
• SE_FIXED - standard error from the fixed-effects model.
• P_FIXED  - P-value from the fixed-effects model.