Potential benefit of Pentraxin 3 use as inflammatory marker in gynecological and obstetric diagnostics

Moskalonek Anna, Mikołajek-Bedner Wioletta, Nurek Karolina, Torbé Dorota, Torbé Andrzej. Potential benefit of Pentraxin 3 use as inflammatory marker in gynecological and obstetric diagnostics. Journal of Education, Health and Sport. 2019;9(3):193-208. eISNN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.2591211

http://ojs.ukw.edu.pl/index.php/johs/article/view/6682

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© The Authors 2019;

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Received: 15.02.2019. Revised: 15.02.2019. Accepted: 12.03.2019.

Potential benefit of Pentraxin 3 use as inflammatory marker in gynecological and obstetric diagnostics

Anna Moskalonek¹, Wioletta Mikołajek-Bedner¹, Karolina Nurek¹, Dorota Torbé², Andrzej Torbé¹

¹Chair and Department of Obstetrics and Gynecology, Pomeranian Medical University in Szczecin, Powstańców Wielkopolskich Av. 72, 70-111 Szczecin Poland

²Doctoral Studium of the Faculty of Health Sciences, Pomeranian Medical University in Szczecin, Żołnierska 54 str., 71-210 Szczecin, Poland

Corresponding author:

Prof. dr hab. n. med. Andrzej Torbé

Chair and Department of Obstetrics and Gynecology

Pomeranian Medical Academy in Szczecin

al. Powstańców Wielkopolskich 72

70-354 Szczecin

Abstract

Pentraxin 3 (PTX3) belongs to the PTX family, which is represented by the short and long arm proteins. Classified as an acute-phase inflammatory response marker, it plays its role in innate immunity. Being produced by macrophages, monocytes, dendritic cells and even tissue cells, it has shown to be one of the most significant indicators of every progressing infection. Certain increased levels of PTX3 have been successfully marked in many disorders and pathologies, giving a powerful feedback in hematology, neurology, as in many cardiovascular, respiratory and inflammatory cases as well. In this review we tried to bring closer the potential of PTX3 usage and underline its possible positive input in the diagnostic phase of the gynecological and obstetric emergencies, based on most recent available researches.

Key words: C-reactive protein, pentraxin 3, preeclampsia, preterm delivery, preterm rupture of membranes