Dataset Open Access

USP5 Zf-UBD Co-Crystal Structure with Compound XSR00035795a & Testing Selectivity

Mann, Mandeep; Tempel, Wolfram; Harding, Rachel; Schapira, Matthieu

Growth of well-diffracting co-crystals of USP5 zinc finger ubiquitin binding domain (Zf-UBD)  and compound XSR00035795a to solve the structure to determine ligand interactions in the binding pocket. A surface plasmon resonance assay was used to determine if methyl group on carboxylic chain of compound XSR00035795a confers selectivity to USP5 versus HDAC6. 

Funding Acknowledgment: The SGC is a registered charity (number 1097737) that receives funds from AbbVie, Bayer Pharma AG, Boehringer Ingelheim, Canada Foundation for Innovation, Eshelman Institute for Innovation, Genome Canada through Ontario Genomics Institute [OGI-055], Innovative Medicines Initiative (EU/EFPIA) [ULTRA-DD grant no. 115766], Janssen, Merck KGaA, Darmstadt, Germany, MSD, Novartis Pharma AG, Ontario Ministry of Research, Innovation and Science (MRIS), Pfizer, São Paulo Research Foundation-FAPESP, Takeda, and Wellcome.
Files (2.2 MB)
Name Size
1_20190301 USP5 cocrystal structure and selectivity.pdf
md5:10790b3c6b186ccb9ff4781b997fa0d4
1.0 MB Download
optimization plate.xls
md5:3fd1f5b2c36c469650254414fc01a375
41.5 kB Download
XSR00035795a.mtz
md5:5677e274d3f6c2d74d273bd76f793bc8
1.0 MB Download
XSR00035795a.pdb
md5:56a6d84e385358c69fc4e645b73b80aa
152.4 kB Download
178
118
views
downloads
All versions This version
Views 178178
Downloads 118118
Data volume 82.3 MB82.3 MB
Unique views 153153
Unique downloads 5858

Share

Cite as