TRAMADOL ABUSE.

The study of tramadol has increased during the last decades, as tramadol has a potential risk to both an individual and the society he/she lives in. However the concept of using tramadol as a painkiller has become a revolution recently. Because of this, all the efforts have been applied in studying this therapeutic drug and the factors for its addiction and abuse. The abuse of the drug among physicians and patients required the study of the physiology and the chemical component of the drug and the regulation of the neurotransmitters through the central nerves system to limit the addiction of the drug. Therefore, knowledge about the chemical and central nervous system cascade will help putting a variety of strategies to tackle the abuse of the drug and its reward pathways for addictive, dependent, and tolerant patients. Moreover knowledge of the symptoms, side effects, and the clinical pharmacology of the drug, will limit the risk factors of the drug. Unintentional abuse or misuse is also a major problem for Tramadol users.